By J. Thomas August, M. W. Anders, Ferid Murad, Joseph T. Coyle
Every one quantity of Advances in Pharmacology offers a wealthy number of reports on well timed subject matters. Emphasis is put on the molecular bases of drug motion, either utilized and experimental.
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Extra info for Advances in Pharmacology, Vol. 39
When traditional antigens or superantigens are presented by APCs and bind to the TCR, activation of a number of tyrosine kinases occurs in the responding T cell. These include the fyn and Ick tyrosine kinases. As a result of the signal transduction cascade, transcription of lymphokines, such as IL-2 and IL-4, is activated. The production of these cytokines leads to the proliferation of T cells and bystander cells, such as B cells and macrophages (Fig. 3 ) . Because superantigens are recognized by a large percentage of T cells, stimulation results in a measurable increase in the percentage of Vp-specific T cells.
J. Surg. Oncol. 24, 83-87. Waddell, W. , Gasner, G. , Cerise, E. , and Loughry, R. W. Sulindac for polyposis of the colon. Am. 1. Surg. 157, 175-178. Williams, C. , Lamps, L. , Nanney, L. , Beauchamp, R. , and DuBois, R. N. (1996). Elevated cyclooxygenase-2 levels in Min mouse adenomas. Gastroenterology 111, 1134-1140. , Gumbinger, H. , and Bunte, H. The NSAID sulindac reverses rectal adenomas in colectomized patients with familial adenomatous polyposis: Clinical results of a dose-finding study on rectal sulindac administration.
And Marnett, L. J. Prostaglandin endoperoxide synthase: Structure and catalysis. Biochim. Biophys. Acta 1083, 1-17. Su, L. , and Kinder, K. W. Association of the APC tumor suppressor protein with catenins. Science 262, 1734-1737. , and Petrelli, N. J. (1993). Aspirin use, cancer, and polyps of the large bowel. Cancer (Philadelphia) 72, 1171-1177. Thun, M. , Namboodiri, M. , and Heath, C. W. J. Aspirin use and reduced risk of fatal colon cancer. N . Engl. J. Med. 325, 1593-1596. , and Valanzano, R.