Amphioxus immunity : tracing the origins of human immunity by An-Long Xu

By An-Long Xu

Amphioxus Immunity: Tracing the beginning of Human Immunity covers a striking variety of data approximately Amphioxus and its evolutionary context. This compilation of what's presently recognized approximately Amphioxus, with a pointy concentrate on its immune procedure, contains thirteen themes, such as:

  • Amphioxus as a version for knowing the evolution of vertebrates
  • basic wisdom of immunology
  • immune organs and cells of amphioxus
  • a genomic and transcriptomic view of the Amphioxus immunity
  • pattern popularity method in Amphioxus
  • transcription components in Amphioxus
  • the supplement approach of Amphioxus
  • the oxidative burst process in Amphioxus
  • immune effectors in Amphioxus
  • lipid signaling of immune reaction in Amphioxus
  • apoptosis in amphioxus; primitive adaptive immune method of Amphioxus
  • and destiny learn directions

This worthy reference ebook is loaded with info that would be beneficial for a person who needs to benefit extra concerning the starting place of vertebrates and adaptive immunity.

  • Provides new facts at the beginning of the adaptive immune procedure, the evolution of innate immunity, and evolution-stage particular immune security mechanisms
  • Not purely offers the cells and molecules thinking about the adaptive immune reaction in Amphioxus, but in addition characterizes the origination and evolution of the gene households and pathways taken with innate immunity
  • Includes a lot pioneering paintings, from the molecular, genomic, and mobile to the person level

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Rev. Immunol. 28, 321–342. , 2005. Molecular genetics of T cell development. Annu. Rev. Immunol. 23, 601–649. , 2006. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. EMBO J. 25, 3257–3263. , 2007. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc. Natl. Acad. Sci. USA 104, 582–587. , 2005. Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3.

The granules in NK cells contain perforins and granzymes, which are responsible for NK cells causing cell lysis. When NK receptors recognize target cells, the perforin and granzymes are activated and deposited in granules to be exocytosed. The granules fuse with the target cell plasma membrane and release granule contents to induce the apoptosis. Tumor necrosis factor (TNF) family members play important roles in this apoptosis. Therefore, even though NK cells do not have T cell receptor or Ig-like receptors, they can kill the dangerous target cells and play an important role in body defense.

2008). In contrast, most host transcripts are masked by a 7-methyl-­guanosine ­capping (mRNA) or removed by processing in the maturation process (tRNA and rRNA). , 2008). , 2014). After the recognition of RNA by RIG-I or MDA5, a complex signaling downstream pathway is activated. , 2005), localizes in the mitochondrial outer membrane and serves as a critical signaling adaptor for RIG-I/MDA5. IPS-1 is composed of an N-terminal CARD domain, by which it interacts with an RIG-I or MDA5 CARD domain.

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