An evidence based guide by Braun L., Cohen M: Herbs and natural supplements.

By Braun L., Cohen M: Herbs and natural supplements.

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Berg). 6 (2004): 501-10. Liptak JM. An overview of the topical management of wounds. 6 (1997): 408-13. Maddocks-Jennings W, Wilkinson JM, Shillington D. Novel approaches to radiotherapy-induced skin reactions: a literature review. 4 (2005): 224-31. McCarty MF. Glucomannan minimizes the postprandial insulin surge: a potential adjuvant for hepatothermic therapy. 6 (2002): 487-90. McCauley RL, Heggers JP, Robson MC. Frostbite: Methods to minimize tissue loss. 8 (1990): 67. McDaniel HR et al. Extended survival and prognostic criteria for acemannan (ACE-M) treated HIV-1 patients.

Beneficial interaction is theoretically possible under professional supervision. G. PARACETAMOL, TRICYCLIC ANTIDEPRESSANTS) Hepatoprotection is possible, according to studies in various experimental models — beneficial interaction. HYPOGLYCAEMIC AGENTS Additive effects are theoretically possible — andrographis has hypoglycaemic activity comparable to that of metformin in vivo. Use together with caution; however, interaction may be beneficial. DRUGS METABOLISED CHIEFLY VIA THE CYTOCHROME P450 SYSTEM It is currently unclear whether there is a significant interaction between andrographis and these medications, as in vivo evidence is suggestive of enzyme induction, but this observation has not yet been investigated in clinical studies (Singh et al 2001).

HEPATOTOXICITY PROTECTION No clinical studies are available; however, several in vivo studies confirm hepatoprotective effects against such hepatotoxins as paracetamol. OTHER USES TRADITIONAL USES The herb is traditionally given as a restorative and tonic in convalescence and used as a choleretic to stimulate bile production and flow, which improves appetite and digestion. It is often used in combination with aromatic herbs, such as peppermint, for stronger digestive effects and to prevent gastrointestinal discomfort at higher doses.

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