Annual Review of Immunology Volume 17 1999 by Annual Reviews

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IL-15 AND ITS RECEPTORS 39 was discussed in part above where it was suggested that IL-15 might contribute to the pathogenesis of RA, inflammatory bowel disease, and sarcoidosis. Furthermore, select malignant cells, for example, multiple myeloma and large granular lymphocytic leukemia cells, express IL-15 receptors (132). In addition, intragraft IL-15 transcripts were increased in patients rejecting renal allografts (133). A correlation existed between IL-15 transcripts within grafts being rejected as compared to nonrejected renal allografts, suggesting that IL15 may play a role in T- and NK-cell-mediated rejection (130).

Selective translation initiation by ribosome jumping in adenovirus-infected and heatshocked cells. Genes Dev. 10:1557–67 70. Nishimura H, Washizu J, Nakamura N, Enomoto A, Yoshikai Y. 1998. Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA. J. Immunol. 160:936–42 71. Hentze MW, Rouault TA, Caughman SW, Dancis W, Harford JB, Klausner RD. 1987. A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in P1: APR/MBG P2: NBL/ary January 21, 1999 46 72.

Bates B, Hardin J, Zhan X, Drickamer K, Goldfarb M. 1991. Biosynthesis of human fibroblast growth factor-5. Mol. Cell. Biol. 11:1840–45 65. Namen AE, Lupton S, Hjerrild K, Wignall J, Mochizuki DY, Schmierer A, Mosley B, March CJ, Urdal D, Gillis S, Cosman D, Goodwin RG. 1988. Stimulation of B-cell progenitors by cloned murine interleukin7. Nature 333:571–73 66. McBratney S, Chen CY, Sarnow P. 1993. Internal initiation of translation. Curr. Opin. Cell. Biol. 5:961–65 67. Belsham GJ, Sonenberg N, Svitkin YV.

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