Annual Review of Immunology Volume 9 1991 by Annual Reviews

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9:27-66. org by HINARI on 08/29/07. For personal use only. Annual Reviews LYMPHOCYTEADHESION AND LOCOMOTION 88~8 ~s 35 Annual Reviews 36 DUSTIN & SPRINGER 66), may contribute to the relatively intact lymphocyte migration in LADpatients. Integrin function appears to be required for invasion of the thymus by thymocyte progenitors during early development (67). novel lymphocyte fl subunit has been found to associate with ~4 to form LPAM-2(~4flP), a receptor for Peyer’s patch endothelial cells (68).

Hibbs, H. Xu, S. A. Stacker, and T. A. Springer, unpublished). It is not knownwhether inside-out signalling stimulates LFA-1avidity by increasing LFA-I affinity for ICAMsor by some other mechanism which increases the number or strength of LFA-1/ICAMinteractions. LFA-1is phosphorylated on both the e and 13 subunit, but these phosphorylations have not been correlated with function (158-160). The presence of conformational flexibility in LFA-1consistent with a change in affinity for ICAMsis detected by two mAbto LFA-1(161, 162).

Consistent with this speculation, fluorescence recovery after photobleachingusing FITClabeled mAbto LFA-3(TS2/9 IgG) indicates that the GPI-anchoredLFA3 diffuses laterally in planar membranes(2 × 10-9 cm2 see-1; 70-90% recovery), while the transmembraneform is immobile(M. L. -Y. Chan, T. A. Springer, L. Ferguson, and D. Golan, unpublished). -Y. Chan, M. Lawrence, M. L. Dustin, and T. A. Springer, unpublished). However,IL-2-activated natural killer cells showsurprisingly poor adhesionto planar membranes bearing GPI-anchoredLFA-3(O.

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