By A. Szenberg (auth.), Albert A. Benedict (eds.)
The ontogeny of lymphoid cells turns out the main applicable position to begin. The early occasions in T and B cellphone ontogeny are nonetheless complicated. There looks no contract at the facts and at the semantics of the query of progenitor vs. stem cells. however, we're starting to comprehend extra approximately progenitor cells that are dedicated to specific telephone strains, and approximately stem cells within the feel of getting virtually limitless potential of giving upward push to undifferentiated progeny. a massive destiny improvement may be to figure out the character of the ingredients that allure stem cells and that are produced by way of really expert thymus epithelium, and maybe through the bursa. the way in which stem cells realize those signs is a vital query to reply to. no longer predictable from mammalian types has been the statement that there's a loss of cells known as into the bursa even earlier than the sign for access of stem cells has been close off. a possible version urged that when a undeniable aspect in improvement there have been not any cells able to migrating into the bursa and changing into B cells. a desirable hazard is the recommendation cellphone comes into the bursa, isn't really dedicated, then can nonetheless wander into the thymus. This mobilephone doesn't seem to have B cellphone characteris tics; that's, immunoglobulin isn't really expressed on its surface.
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We also used yolk sac cells from 9, 11, 13, 15 and lS days of incubation. With these cells no effect either on the morphology (Table 4) or on immune functions of the cell recipients was obtained. J. ESKOLA AND P. TOIVANEN 42 Table 3 Transplantation of 15-day embryonic cells into cyc1ophosphamide(CY)treated embryos; effect on body and organ weights measured at the age of 36 days. Mean values are given. CY Cells Body + weight Bursa weight§ + + + + + + Bursa Marrow Spleen Thymus Liver 214 268 233 225 223 228* 309 82* 199* 110* 119 91 91 402 Sp1een§ weight 209 212 209 239 195 190 230 Thymus§ weight 145 209* 180 166 145 136* 274 + In grams § Mg/100 g of body weight ~ ~ ~:~gl} when compared to CY-treated controls !
Closed circles represent the mean numbers of CFU's per spleen. Open circles represent the mean numbers of lymphoid colonies per spleen. Donors and recipients were both B2/B2. Arrow along the abscissa indicates the day of hatching. Vertical bars represent standard error of the mean. Section of lymphoid colony, derived from a 2-day-old chicken spleen, on the CAM of a chicken embryo. The majority of cells in this colony have the characteristics of lymphocytes (x 480). Hematoxylin - Eosin stain. 26 G.
PRODUCTION OF A CHEMOTACTIC FACTOR BY THYMIC AND BURSIC RUDIMENTS : A POSSIBLE MECHANISM TO EXPLAIN THE STEM CELL INVASION. Several types of experiment have been devised to see whether the thymic and bursic anlagen attract the circulating haemocytoblasts through the production of a chemotactic substance. The general experimental design consisted in the interspecific association of thymic and bursic rudiments ready to be colonized with various sources of stem cells which were either thymuses or bursas already populated but in which lymphoi d differentiation had not yet started or was only just beginning.