Bacterial vaccines by Ronald W Ellis; Bernard R Brodeur

By Ronald W Ellis; Bernard R Brodeur

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2. Vaccines, Bacterial. In: Lederberg J, ed. Encyclopedia of Microbiology. 2nd ed. San Diego: Academic Press, 2000:767-778 3. Hayrinen J, Jennings H, Raff HV et al. Antibodies to polysialic acid and its N-propyl derivative: binding properties and interaction with human embryonal brain glycopeptides. J Infect Dis 1995 ; 171:1481-1490. 4. Finne J, Bitter-Suermann D, Goridis C et al. An IgG monoclonal antibody to group B meningococci cross-reacts with developmentally regulated polysialic acid units of glycoproteins in neural and extraneural tissues.

With other gram negative encapsulated bacteria, however, variations in serotypes that can cause disease create a different paradigm. In the case of Group B Streptococcus (GBS), Neisseria meningitidis and Streptococcus pneumoniae there are at least 9, 12 and 90 different capsular Ps serotypes, respectively. In addition, the N. meningitidis group B capsular Ps is poorly immunogenic and is identical to polysialic acid found on normal human tissues. 3,4 Finally, preliminary data suggest that vaccination with multivalent conjugated Ps may result in substitution of colonizing serotypes not included in the vaccine.

Coli and the recombinant proteins purified. BALB/c mice were immunized subcutaneously with either recombinant protein two or three times at 3-week intervals. Good antibody responses were observed in ELISA, and immunoblots revealed that antibodies raised to recombinant BVH-3 and BVH-11 proteins recognized the native S. pneumoniae antigens. Moreover, cytofluorometry studies on live bacterial cells using mouse sera indicated that both proteins are exposed at the surface of homologous and heterologous strains.

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