Carbohydrate-Based Vaccines and Immunotherapies by Binghe Wang(eds.)

By Binghe Wang(eds.)

The basic technology and the newest advancements in carbohydrate-based vaccines

The really new box of glycoimmunology has emerged from the wedding of glycobiology and immunology, in attractiveness of the $64000 position carbohydrates play as antigenic determinants. Carbohydrate-Based Vaccines and Immunotherapies comprehensively stories the country of this fascinating box, supplying a unmarried resource for either the basic technology and the most recent advancements.

With contributions by means of best specialists, this source covers the layout, synthesis, overview, and functions of assorted carbohydrate-based vaccines, together with polysaccharides, neoglycoproteins, and neoglycolipids. The textual content ways vaccine layout from a chemical and molecular concentration, staying in keeping with present advances.

Key themes lined through Carbohydrate-Based Vaccines and Immunotherapies comprise:

  • contemporary advancements in the direction of clinically beneficial vaccines opposed to micro organism, viruses, parasites, and fungi

  • utilizing adjuvants to enhance immunogenicity and/or immunological houses of vaccines

  • settling on and designing right adjuvants for particular pursuits

  • irregular carbohydrates expressed by means of tumors

  • Carbohydrate-based healing melanoma vaccines or melanoma immunotherapy

  • medical trials effects for artificial melanoma vaccines

  • Glycoengineering of phone floor carborhydrates and its anticancer functions

  • utilizing phone floor carbohydrates for illness analysis

A unmarried, handy resource of state of the art info from prime specialists within the box, Carbohydrate-Based Vaccines and Immunotherapies is a necessary reference for natural chemists and biochemists, educational researchers, and different scholars and execs keen on vaccine design.Content:
Chapter 1 Glycobiology and Immunology (pages 1–53): Udayanath Aich and Kevin J. Yarema
Chapter 2 training of Glycoconjugate Vaccines (pages 55–88): Wei Zou and Harold J. Jennings
Chapter three Adjuvants for Protein? and Carbohydrate?Based Vaccines (pages 89–115): Bruno Guy
Chapter four Carbohydrate?Based Antibacterial Vaccines (pages 117–166): Robert A. Pon and Harold J. Jennings
Chapter five Carbohydrate?Based Antiviral Vaccines (pages 167–193): Benjamin M. Swarts and Zhongwu Guo
Chapter 6 Carbohydrate?Based Antiparasitic Vaccines (pages 195–214): Faustin Kamena, Xinyu Liu and Peter H. Seeberger
Chapter 7 Carbohydrate?Based Antifungal Vaccines (pages 215–226): Magdia De Jesus, Liise?Anne Pirofski and Arturo Casadevall
Chapter eight Cancer?Associated and comparable Glycosphingolipid Antigens (pages 227–262): Steven B. Levery
Chapter nine Semisynthetic and entirely artificial Carbohydrate?Based melanoma Vaccines (pages 263–311): Therese Buskas, Pamela Thompson and Geert?Jan Boons
Chapter 10 Glycoengineering of cellphone floor Sialic Acid and Its program to melanoma Immunotherapy (pages 313–331): Zhongwu Guo
Chapter eleven healing melanoma Vaccines: scientific Trials and purposes (pages 333–366): Hans H. Wandall and Mads A. Tarp
Chapter 12 Carbohydrates as exact buildings for affliction prognosis (pages 367–394): Kate Rittenhouse?Olson

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4 and in detail in Chapters 2 and 4). 1 GLYCOBIOLOGY AND IMMUNOLOGY THE IMMUNE SYSTEM Introductory Comments Now that glycosylation has been briefly outlined, we will next provide an even less thorough, but hopefully helpful for the nonspecialist, overview of the immune system. Clearly, immunity is a huge topic—with well over one million articles available through searches of computer databases such as PubMed [35]—therefore, at the outset we emphasize that we provide a “bare-bones” discussion just sufficient to place into context some of the intriguing connections between glycosylation and immunity, and we trust that the valued reader will not feel slighted if his or her favorite aspect of the immune system is omitted in this chapter.

4b, top)—are much larger with sizes of 100 monosaccharide residues or greater being commonplace. 6d—in the majority of cases GAGs are free of explicit surface entanglements and instead exist as part of the proteoglycan component of the extracellular matrix (ECM). The major GAGs of physiological significance are hyaluronic acid, dermatan sulfate, chondroitin sulfate, heparin, heparin sulfate, and keratan sulfate. While each has a distinctive molecular composition, all GAGs are based on disaccharide units that contain either GalNAc or GlcNAc combined with one of two uronic acids (glucuronate or iduronate).

The most prevalent type of O-glycan arises from mucin-type glycosylation, where N-acetyl-D-galactosamine (GalNAc) is attached to a Ser or Thr through an a linkage [73] (Fig. 6a). In general, O-linked glycans are an unruly bunch compared to their N-linked siblings; first, they are not confined to a consensus sequence but can seemingly occur on any Ser or Thr. Second, they are not limited to a single type of monosaccharide used to link the sugar to the peptide [57] but commonly use GalNAc, GlcNAc, and xylose-linked O-glycans (Fig.

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