Dendritic Spines by Rafael Yuste

By Rafael Yuste

A number one neurobiologist explores the elemental functionality of dendritic spines in neural circuits through reading diverse facets in their biology, together with constitution, improvement, motility, and plasticity.

Show description

Read or Download Dendritic Spines PDF

Similar immunology books

Human Antibody Therapeutics For Viral Disease (Current Topics in Microbiology and Immunology)

Even supposing the software of human antibodies as scientific therapeutics for melanoma and immune ailments has been well-established, it's only starting to be discovered for the remedy of viral infectious illnesses. Polyclonal immunoglobulins have lengthy been used for a few viral ailments, yet they've got restricted efficiency and illness scope.

The Tumor Immunoenvironment

Research of multidirectional immunological responses on the tumor website permits forming a brand new idea of The Tumor Immunoenvironment, that is brought and mentioned within the current e-book with a selected specialise in the position of immune cells in controlling the tumor microenvironment at varied phases of melanoma improvement.

Antibodies in cell biology

Antibodies in telephone Biology makes a speciality of a brand new new release of protocols geared toward the phone biologist. This laboratory handbook positive factors structures and strategies which are particularly appropriate for contemporary difficulties. The contributing authors were conscientiously selected for his or her particular services, and feature supplied precise protocols, recipes, and troubleshooting publications in every one bankruptcy.

Extra info for Dendritic Spines

Example text

2006. 22 Spines in humans are larger and more abundant than in mice. (A, B). Low-power photomicrographs of layer 3 pyramidal cells from human (A) and mouse (B) temporal cortex, injected in fixed sections with Lucifer Yellow. Note the smaller size of mouse neurons. Sections are parallel to the cortical surface. (C, D) Photomicrograph of horizontally projecting dendrites of a human (C) and mouse (D) pyramidal cells. (E, F) High-power photomicrographs of the basal dendrite segments of human (E) and mouse (F) pyramidal cells, illustrating individual dendritic spines.

The neck is sometimes too lightly ´ lvarez, stained’’ (copy of autograph letter to Lorente, courtesy of Dr. Francisco A Creighton University, trans. by the author). 5). 16 Chapter 2 Discovery 17 In spite of this string of arguments and the combined weight of his evidence, Cajal’s conclusions took a long time to be accepted. Eventually, many of his contemporaries, such as Retzius, Scha¤er, Edinger, Azolay, Berkley, Monti, and Stefanowska, came to agree with him and confirmed the appearance of spines in their preparations.

13D). , 2006). , 2007a). Thus, it is safe to assume that, while for most spines, the spine neck and head appear to be independently regulated, for a subset of spines, those with larger heads tend to have broader necks. The significance of this special case is unclear, and will be addressed in later chapters. As will be discussed later as well (chapters 7, 8, and 9), the spine neck length also has a direct functional relevance, since it can regulate the degree of biochemical isolation of the spine from its parent dendrite and play a major role in the electrical filtering (or amplification) of synaptic currents injected at the head of the spine.

Download PDF sample

Rated 4.16 of 5 – based on 41 votes